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產(chǎn)品規(guī)格
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BN41294R-100ul
100ul
￥2360.00
交叉反應(yīng)：Mouse(predicted:Human) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA
BN41294R-200ul
200ul
￥3490.00
交叉反應(yīng)：Mouse(predicted:Human) 推薦應(yīng)用：WB,IHC-P,IHC-F,IF,ELISA
產(chǎn)品描述
| 英文名稱 | CDAN1 |
| 中文名稱 | 先天性紅細胞生成異常性貧血蛋白1抗體 |
| 別 名 | Alternative namesCDA1; CDAI; CDAN1; CDAN1_HUMAN; Codanin; Codanin-1; Codanin1; PRO1295. |
| 研究領(lǐng)域 | 心血管 細胞生物 免疫學 |
| 抗體來源 | Rabbit |
| 克隆類型 | Polyclonal |
| 交叉反應(yīng) | Mouse, (predicted: Human, ) |
| 產(chǎn)品應(yīng)用 | WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)） not yet tested in other applications. optimal dilutions/concentrations should be determined by the end user. |
| 分 子 量 | 56/130kDa |
| 細胞定位 | 細胞膜 |
| 性 狀 | Liquid |
| 濃 度 | 1mg/ml |
| 免 疫 原 | KLH conjugated synthetic peptide derived from human CDAN1:1175-1227/1227 |
| 亞 型 | IgG |
| 純化方法 | affinity purified by Protein A |
| 儲 存 液 | 0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol. |
| 保存條件 | Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles. |
| PubMed | PubMed |
| 產(chǎn)品介紹 | This gene encodes a protein that appears to play a role in nuclear envelope integrity, possibly related to microtubule attachments. Mutations in this gene cause congenital dyserythropoietic anemia type I, a disease resulting in morphological and functional abnormalities of erythropoiesis. Function: Might be involved in nuclear membrane integrity. Subcellular Location: Membrane; Multi-pass membrane protein. Tissue Specificity: Ubiquitously expressed. Isoform 3 is not found in erythroid cells. DISEASE: Defects in CDAN1 are the cause of congenital dyserythropoietic anemia type 1 (CDA1) [MIM:224120]. An autosomal recessive blood disorder characterized by morphological abnormalities of erythroblasts, ineffective erythropoiesis, macrocytic anemia and secondary hemochromatosis. It is occasionally associated with bone abnormalities, especially of the hands and feet (acrodysostosis), nail hypoplasia, and scoliosis. Ultrastructural features include internuclear chromatin bridges connecting some nearly completely separated erythroblasts and an abnormal appearance (spongy or Swiss-cheese appearance) of the heterochromatin in a high proportion of the erythroblasts. SWISS: Q8IWY9 Gene ID: 146059 Database links: Entrez Gene: 146059 Human Entrez Gene: 68968 Mouse Omim: 607465 Human SwissProt: Q8IWY9 Human SwissProt: Q8CC12 Mouse Unigene: 599232 Human Unigene: 2289 Mouse Important Note: This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. |
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